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Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer

Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung Jin Lee, Junbo Gong, Huining He, Victor C. Yang

《化学科学与工程前沿（英文）》 2017年 第11卷 第4期   页码 529-536 doi: 10.1007/s11705-017-1645-z

摘要： An anticancer drug delivery system consisting of DNA nanoparticles synthesized by rolling circle amplification (RCA) was developed for prostate cancer membrane antigen (PSMA) targeted cancer therapy. The template of RCA was a DNA oligodeoxynucleotide coded with PSMA-targeted aptamer, drug-loading domain, primer binding site and pH-sensitive spacer. Anticancer drug doxorubicin, as the model drug, was loaded into the drug-loading domain (multiple GC-pair sequences) of the DNA nanoparticles by intercalation. Due to the integrated pH-sensitive spacers in the nanoparticles, in an acidic environment, the cumulative release of doxorubicin was far more than the cumulative release of the drug in the normal physiological environment. In cell uptake experiments, treated with doxorubicin loaded DNA nanoparticles, PSMA-positive C4-2 cells could take up more doxorubicin than PSMA-null PC-3 cells. The prepared DNA nanoparticles showed the potential as drug delivery system for PSMA targeting prostate cancer therapy.

关键词： aptamer     DNA nanoparticles     rolling circle amplification     doxorubicin     drug delivery     pH sensitive    

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Application of digital holography to circle flow bed boiler measurement

PU Shiliang, WANG Qinghui, CEN Kefa, Denis Lebrun, REN Kuanfang

《能源前沿（英文）》 2007年 第1卷 第2期   页码 218-222 doi: 10.1007/s11708-007-0029-3

摘要： The spatial distribution of particles in the boiler is very important in the study on the circle flow bed boiler (CFB). Digital in-line holography technique was applied to obtain the spatial and diameter distribution of the particles inside the boiler. A HE-NE laser was used to illuminate the particles inside the CFB through two glass windows and the in-line diffraction pattern was recorded by a CCD camera. The diffraction can be interpreted as a convolution between a family of wavelet functions and the object function. So the three-dimensional (3D) images of the particles in the two-phase flow were reconstructed by the convolution between diffraction pattern and wavelet functions. The particle diameters and 3D coordinates were calculated from the reconstructed 3D images by a series of image-processing methods, followed by a discussion of the experimental results.

关键词： HE-NE     function     convolution     two-phase     diffraction    

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A rolling 6U parallel mechanism

Zhihuai MIAO, Yanan YAO

《机械工程前沿（英文）》 2011年 第6卷 第1期   页码 96-98 doi: 10.1007/s11465-011-0214-2

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Novel probabilistic rolling regular tetrahedron mechanism

Yonghan GUAN, Yan’an YAO, Chao LIU, Ruiming LI

《机械工程前沿（英文）》 2021年 第16卷 第2期   页码 363-378 doi: 10.1007/s11465-020-0628-9

摘要： With recent relevant publications on stochastic motion robots in , , and other journals, research on such robots has gained increasing attention. However, theoretical and applied research on stochastic motion in the field of robotics and mechanisms face many challenges due to the uncertainty of stochastic motion. Currently, a large gap remains in the research of stochastic motion mechanism. In this study, a novel mechanism that can conduct probabilistic rolling is proposed to reach a designated position and achieve overlying movement over a particular area. The mechanism consists of a regular tetrahedron frame, a central node, and four connecting linear actuators. According to mobility and kinematic analyses, the mechanism can implement probabilistic rolling. Each rolling gait has three probable rolling directions, and the mechanism rolls in one of the three directions in probability. A kinematic simulation is conducted, and a control method is proposed on the basis of the moving path analysis. Furthermore, the mathematical principle of probabilistic rolling is revealed in terms of probability theory and statistics. Lastly, a prototype is fabricated. To achieve the rolling function, the design of the linear actuators is improved, and the extension ratio is increased from 0.58 to 1.13. Then, tests are conducted. In a 4 m test site, the mechanism makes 11 moves to reach the target position and covers 29.25% of the site.

关键词： mobile mechanism     probabilistic motion     rolling mechanism     stochastic motion    

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A rolling 3-UPU parallel mechanism

Zhihuai MIAO, Yan’an YAO, Xianwen KONG

《机械工程前沿（英文）》 2013年 第8卷 第4期   页码 340-349 doi: 10.1007/s11465-013-0282-6

摘要：

A novel rolling mechanism is proposed based on a 3-UPU parallel mechanism in this paper. The rolling mechanism is composed of two platforms connected by three UPU (universal-prismatic-universal) serial-chain type limbs. The degree-of-freedom of the mechanism is analyzed using screw theory. Gait analysis and stability analysis are presented in detail. Four rolling modes of the mechanism are discussed and simulated. The feasibility of the rolling mechanism is verified by means of a physical prototype. Finally, its terrain adaptability is enhanced through planning the rolling gaits.

关键词： parallel mechanism     rolling mechanism     screw theory    

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Research and industrialization of near-net rolling technology used in shaft parts

Zhenghuan HU, Baoyu WANG, Zhenhua ZHENG

《机械工程前沿（英文）》 2018年 第13卷 第1期   页码 17-24 doi: 10.1007/s11465-018-0480-3

摘要：

Shaft part rolling is an efficient and green near-net shaping technology offering many advantages, including high production efficiency, high material utilization rate, high product quality, and excellent production environment. In this paper, the features of shaft part rolling are introduced along with the working principles of two main shaft part rolling technologies, namely, cross wedge rolling (CWR) and skew rolling (SR). In relation to this technology, some R&D achievements gained by the University of Science and Technology Beijing are summarized. Finally, the latest developments in shaft part rolling are presented, including SR steel balls, precise forming of camshaft blank by CWR, SR phosphorous copper balls at room temperature, and CWR hollow axle sleeve. Although the shaft part rolling technology has been widely used in China, it only accounts for about 15% of applicable parts at present. Nevertheless, this technology has broad application prospects.

关键词： cross wedge rolling     skew rolling     near-net rolling     shaft part    

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Numerical investigation of circle defining curve for two-dimensional problem with general boundaries

Chung Nguyen VAN

《结构与土木工程前沿（英文）》 2019年 第13卷 第1期   页码 92-102 doi: 10.1007/s11709-018-0472-8

摘要： The scaled boundary finite element method (SBFEM) is applied to the static analysis of two dimensional elasticity problem, boundary value problems domain with the domain completely described by a circular defining curve. The scaled boundary finite element equations is formulated within a general framework integrating the influence of the distributed body force, general boundary conditions, and bounded and unbounded domain. This paper investigates the possibility of using exact geometry to form the exact description of the circular defining curve and the standard finite element shape function to approximate the defining curve. Three linear elasticity problems are presented to verify the proposed method with the analytical solution. Numerical examples show the accuracy and efficiency of the proposed method, and the performance is found to be better than using standard linear element for the approximation defining curve on the scaled boundary method.

关键词： exact geometry     circular defining curve     general boundaries     SBFEM    

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海洋渔业碳汇及其扩增战略

唐启升,刘 慧

《中国工程科学》 2016年 第18卷 第3期   页码 68-73 doi: 10.15302/J-SSCAE-2016.03.011

摘要：

本文介绍了海洋渔业碳汇和碳汇渔业的定义、研究现状、问题及技术需求。与林业碳汇比较结果表明，海洋渔业碳汇不仅有高效的特性，还有扩增的潜质。为此，提出海洋渔业碳汇扩增对策建议，主要包括：查明我国海洋渔业碳汇潜力及动态机制；大力发展以海水养殖为主体的碳汇渔业；加强近海自然碳汇及其环境的养护和管理；实施相应的渔业碳汇扩增工程建设，促进环境友好型水产养殖业发展。

关键词： 海洋渔业碳汇     碳汇渔业     碳汇扩增     养护和管理     贝藻养殖    

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板带轧制工艺控制理论概要

张进之

《中国工程科学》 2001年 第3卷 第4期   页码 46-55

摘要：

以最小阻力定律、体积不变条件和秒流量相等条件为内容的经典轧制理论，经试验、演绎形成了较完整的轧制应用技术科学体系，这种体系所反映的是静态规律。在轧制理论发展中引入控制论、信息论、计算机科学等高新技术，对轧制过程进行控制。在轧制理论发展史上，弹跳方程建立之前是以力学为基础建立的经典轧制理论，之后为以力学和控制论为基础建立的基本轧制工艺控制理论。文章提出工艺控制理论概念，是在基本轧制工艺控制理论的基础上建立的新的理论体系，主要内容包括：在连轧张力理论中反映了张力的负反馈，建立了连轧张力理论体系；在厚控过程中，解决扰动的检测问题；在板形理论中，定义了对偶参数，确立了与 厚控理论相似的板形理论体系。

关键词： 连轧过程控制     连轧张力     厚度控制     板形刚度     轧机弹跳方程     综合等储备负荷分配    

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Rolling-element bearings in China: From ancient times to the 20th century

Lie SUN,Ang LI

《机械工程前沿（英文）》 2016年 第11卷 第1期   页码 33-43 doi: 10.1007/s11465-016-0373-2

摘要：

The development of rolling-element bearings in China has spanned a long period. Based on several typical and important cases, the present article reconstructs the history of rolling-element bearings in China by dividing it into four stages according to the various characteristics of the bearings. The first stage represents the origin of rolling bearings in China, which remains controversial because of several suspected races and cages that were likely the components of bearings more than a millennium ago. At the second stage, a type of simple roller bearing was used for astronomical instruments not later than the 13th century based on clear philological and physical evidence. A similar bearing was also applied to an abridged armillary in the 17th century. Another type of spherical thrust bearings with rolling elements, which is a key component of a traditional Chinese windmill, could support a rotating shaft that moves rotationally and at an angle. At the third stage, the Chinese began studying and using the so-called European-style bearing since the 17th century. Moreover, over the last 100 years, the modern rolling bearing industry was gradually established in China, particularly because of the technology transfer from the Soviet Union in the 1950s. At the fourth stage, the Chinese government initiated the relatively rapid development of bearing technology. The government launched the “bearing movement” from the 1950s to the 1960s to establish the modern bearing industry and to promote rolling bearings as replacement for traditional sliding bearings. Furthermore, a number of large professional factories and institutions in China have continually introduced advanced technology and equipment. At present, these companies and institutions play a significant role in the international bearing industry.

关键词： bearing movement     rolling-element bearing     China     early rolling bearings     technology transfer    

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simulation and analysis of periodically oscillating pressure characteristics of inviscid flow in a rolling

Yan GU, Yonglin JU

《能源前沿（英文）》 2012年 第6卷 第1期   页码 21-28 doi: 10.1007/s11708-012-0173-2

摘要： Floating liquefied natural gas (LNG) plants are gaining increasing attention in offshore energy exploitation. The effects of the periodically oscillatory motion on the fluid flow in all processes on the offshore plant are very complicated and require detailed thermodynamic and hydrodynamic analyses. In this paper, numerical simulations are conducted by computational fluid dynamics (CFD) code combined with user defined function (UDF) in order to understand the periodically oscillating pressure characteristics of inviscid flow in the rolling pipe. The computational model of the circular pipe flow is established with the excitated rolling motion, at the excitated frequencies of 1–4 rad/s, and the excitated amplitudes of 3°–15°, respectively. The influences of flow velocities and excitated conditions on pressure characteristics, including mean pressure, frequency and amplitude are systematically investigated. It is found that the pressure fluctuation of the inviscid flow remains almost constant at different flow velocities. The amplitude of the pressure fluctuation increases with the increasing of the excitated amplitude, and decreases with the increasing of the excitated frequency. It is also found that the period of the pressure fluctuation varies with the excitated frequency. Furthermore, theoretical analyses of the flow in the rolling circular pipe are conducted and the results are found in qualitative agreement with the numerical simulations.

关键词： pressure fluctuation     rolling     floating production storage and offloading unit for liquefied natural gas (LNG-FPSO) offshore    

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Effect of end-to-end invagination pancreaticojejunostomy with circle discontinuous U suture in pancreatic

ZHANG Xuewen, XUAN Wei, JIANG Tao, JI Degang, YANG Yongsheng, ZHANG Dan, XIE Yingjun, MENG Zihui, ZHAO Jisheng

《医学前沿（英文）》 2007年 第1卷 第1期   页码 46-48 doi: 10.1007/s11684-007-0009-3

摘要： The aim of this paper is to summarize the methods of pancreaticojejunostomy in the pancreatic operation and to study the safety and feasibility of a new operative method called end-to-end invagination pancreaticojejunostomy with circle discontinuous U suture to prevent fistula of pancreaticojejunostomy. Eight-three patients with pancreaticoduodenectomy in the 3rd Hospital, Jilin University from 2001 January to 2006 April were reviewed. The incidences of pancreatic fistula with different types of pancreaticojejunostomy were compared. The overall incidence rate of pancreatic fistula was 26.5% (22/83). No pancreatic fistula occurred in end-to-end invagination pancreaticojejunostomy with circle discontinuous U suture. The incidence rate of the fistula following end-to-end invagination pancreaticojejunostomy with circle discontinuous U suture was significantly lower than that of traditional end-to-end pancreaticojejunostomy [40%, (10/25), <0.01] and end-to-side pancreaticojejunostomy [27.3%, (12/44), <0.05], but no significant difference (>0.05) between traditional end-to-end pancreaticojejunostomy and end-to-side pancreaticojejunostomy was discovered. End-to-end invagination pancreaticojejunostomy with circle discontinuous U suture has a definite effect on avoiding pancreatic fistula following pancreaticojejunostomy and is worth being recommended. But the cases were limited, so this method would still need to be observed and confirmed further in the future.
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Review of the damage mechanism in wind turbine gearbox bearings under rolling contact fatigue

Yun-Shuai SU, Shu-Rong YU, Shu-Xin LI, Yan-Ni HE

《机械工程前沿（英文）》 2019年 第14卷 第4期   页码 434-441 doi: 10.1007/s11465-018-0474-1

摘要： Wind turbine gearbox bearings fail with the service life is much shorter than the designed life. Gearbox bearings are subjected to rolling contact fatigue (RCF) and they are observed to fail due to axial cracking, surface flaking, and the formation of white etching areas (WEAs). The current study reviewed these three typical failure modes. The underlying dominant mechanisms were discussed with emphasis on the formation mechanism of WEAs. Although numerous studies have been carried out, the formation of WEAs remains unclear. The prevailing mechanism of the rubbing of crack faces that generates WEAs was questioned by the authors. WEAs were compared with adiabatic shear bands (ASBs) generated in the high strain rate deformation in terms of microstructural compositions, grain refinement, and formation mechanism. Results indicate that a number of similarities exist between them. However, substantial evidence is required to verify whether or not WEAs and ASBs are the same matters.

关键词： rolling contact fatigue (RCF)     white etching area (WEA)     white etching crack (WEC)     adiabatic shear band (ASB)    

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Durability of plasma-sprayed Cr3C2-NiCr coatings under rolling contact conditions

Xiancheng ZHANG, Fuzhen XUAN, Shantung TU, Binshi XU, Yixiong WU

《机械工程前沿（英文）》 2011年 第6卷 第1期   页码 118-135 doi: 10.1007/s11465-011-0127-0

摘要：

The aim of this paper was to address the rolling contact fatigue (RCF) failure mechanisms of plasma-sprayed Cr3C2-NiCr coatings under different tribological conditions of contact stress. Weibull distribution plots of fatigue lives of the coated specimens at different contact stresses were obtained. The failure modes of coatings were identified on the basis of wore surface observations of the failed coatings. Results showed that the RCF failure modes can be classified into four main categories, i.e., surface abrasion, spalling, cohesive delamination, and interfacial delamination. The probabilities of the surface abrasion and spalling type failures were relatively high at low contact stress. When the coatings were subjected to abrasion and spalling type failures, the failure of the coating was depended on the microstrcture of the coating. The stress concentration near the micro-defects in the coating may be the may reason for the formation of spall. The coatings were prone to fail in delamination under higher contact stresses. However, the delamination of coating may be related to distribution of shear stress amplitude within coating. The location of maximum shear stress amplitude can be used as a key parameter to predict the initiation of subsurface cracks within coating in rolling contact.

关键词： rolling contact fatigue     coating     Weibull distribution     failure mode     mechanism    

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An adaptive data-driven method for accurate prediction of remaining useful life of rolling bearings

Yanfeng PENG, Junsheng CHENG, Yanfei LIU, Xuejun LI, Zhihua PENG

《机械工程前沿（英文）》 2018年 第13卷 第2期   页码 301-310 doi: 10.1007/s11465-017-0449-7

摘要：

A novel data-driven method based on Gaussian mixture model (GMM) and distance evaluation technique (DET) is proposed to predict the remaining useful life (RUL) of rolling bearings. The data sets are clustered by GMM to divide all data sets into several health states adaptively and reasonably. The number of clusters is determined by the minimum description length principle. Thus, either the health state of the data sets or the number of the states is obtained automatically. Meanwhile, the abnormal data sets can be recognized during the clustering process and removed from the training data sets. After obtaining the health states, appropriate features are selected by DET for increasing the classification and prediction accuracy. In the prediction process, each vibration signal is decomposed into several components by empirical mode decomposition. Some common statistical parameters of the components are calculated first and then the features are clustered using GMM to divide the data sets into several health states and remove the abnormal data sets. Thereafter, appropriate statistical parameters of the generated components are selected using DET. Finally, least squares support vector machine is utilized to predict the RUL of rolling bearings. Experimental results indicate that the proposed method reliably predicts the RUL of rolling bearings.

关键词： Gaussian mixture model     distance evaluation technique     health state     remaining useful life     rolling bearing    

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标题 作者 时间 类型 操作

Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer

Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung Jin Lee, Junbo Gong, Huining He, Victor C. Yang

期刊论文

Application of digital holography to circle flow bed boiler measurement

PU Shiliang, WANG Qinghui, CEN Kefa, Denis Lebrun, REN Kuanfang

期刊论文

A rolling 6U parallel mechanism

Zhihuai MIAO, Yanan YAO

期刊论文

Novel probabilistic rolling regular tetrahedron mechanism

Yonghan GUAN, Yan’an YAO, Chao LIU, Ruiming LI

期刊论文

A rolling 3-UPU parallel mechanism

Zhihuai MIAO, Yan’an YAO, Xianwen KONG

期刊论文

Research and industrialization of near-net rolling technology used in shaft parts

Zhenghuan HU, Baoyu WANG, Zhenhua ZHENG

期刊论文

Numerical investigation of circle defining curve for two-dimensional problem with general boundaries

Chung Nguyen VAN

期刊论文

海洋渔业碳汇及其扩增战略

唐启升,刘 慧

期刊论文

板带轧制工艺控制理论概要

张进之

期刊论文

Rolling-element bearings in China: From ancient times to the 20th century

Lie SUN,Ang LI

期刊论文

simulation and analysis of periodically oscillating pressure characteristics of inviscid flow in a rolling

Yan GU, Yonglin JU

期刊论文

Effect of end-to-end invagination pancreaticojejunostomy with circle discontinuous U suture in pancreatic

ZHANG Xuewen, XUAN Wei, JIANG Tao, JI Degang, YANG Yongsheng, ZHANG Dan, XIE Yingjun, MENG Zihui, ZHAO Jisheng

期刊论文

Review of the damage mechanism in wind turbine gearbox bearings under rolling contact fatigue

Yun-Shuai SU, Shu-Rong YU, Shu-Xin LI, Yan-Ni HE

期刊论文

Durability of plasma-sprayed Cr3C2-NiCr coatings under rolling contact conditions

Xiancheng ZHANG, Fuzhen XUAN, Shantung TU, Binshi XU, Yixiong WU

期刊论文

An adaptive data-driven method for accurate prediction of remaining useful life of rolling bearings

Yanfeng PENG, Junsheng CHENG, Yanfei LIU, Xuejun LI, Zhihua PENG

期刊论文